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Aminobenzoate degradation

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
5-methoxygallic_acid + O2 <=> H+ + 2-Pyrone-4,6-dicarboxylate + methanol 1.13.11
1.13.11.8 protocatechuate 4,5-dioxygenase


4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate <=> 2-Pyrone-4,6-dicarboxylate + methanol not assigned

benzaldehyde + H2O + NAD+ <=> aromatic_carboxylate + NADH + H+ 1.1.1.1 alcohol dehydrogenase
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.29 aryl-aldehyde dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.31 L-aminoadipate-semialdehyde dehydrogenase
1.2.1.48 long-chain-aldehyde dehydrogenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase
1.2.1.67 vanillin dehydrogenase
1.2.1.69 fluoroacetaldehyde dehydrogenase













benzoylformate + H+ <=> CO2 + benzaldehyde 4.1.1.1 pyruvate decarboxylase
4.1.1.7 benzoylformate decarboxylase
4.1.1.72 branched-chain-2-oxoacid decarboxylase
4.1.1.74 indolepyruvate decarboxylase




H+ + 1,4-benzoquinone + NADPH <=> hydroquinone + NADP+ 1.1.1.328 nicotine blue oxidoreductase
1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.6.5.10 NADPH dehydrogenase (quinone)
1.6.5.2 NAD(P)H dehydrogenase (quinone)
1.6.5.5 NADPH:quinone reductase
1.6.5.6 p-benzoquinone reductase (NADPH)
1.7.1.6 azobenzene reductase
1.8.1.9 thioredoxin-disulfide reductase








4-sulfomuconolactone + H2O <=> maleylacetate + sulfite + H+ 3.1.1.92 4-sulfomuconolactone hydrolase

gallic_acid + O2 <=> 4-oxalomesaconate + H+ 1.13.11.57 gallate dioxygenase
1.13.11.8 protocatechuate 4,5-dioxygenase


2-hydroxy-1,4-benzoquinone + NADH + H+ <=> Hydroxyquinol + NAD+ 1.6.5.7 2-hydroxy-1,4-benzoquinone reductase
1.8.1.4 dihydrolipoyl dehydrogenase


O2 + Vanillyl_alcohol <=> Vanillin + H2O2 1.1.3.38 vanillyl-alcohol oxidase
1.1.3.47 5-(hydroxymethyl)furfural oxidase
1.1.3.7 aryl-alcohol oxidase



2-Pyrone-4,6-dicarboxylate + H2O <=> 4-oxalomesaconate + H+ 3.1.1.57 2-pyrone-4,6-dicarboxylate lactonase

(S)-Mandelate + FMN <=> benzoylformate + FMNH2 1.1.99.31 (S)-mandelate dehydrogenase

nitrosobenzene + NADP+ + H2O <=> 4-nitrophenyl + NADPH + H+ 1.7.1.16 nitrobenzene nitroreductase

Hydroxyquinol <=> 2-hydroxy-1,4-benzoquinone 1.1

H+ + 3-sulfomuconate <=> 4-sulfomuconolactone 5.5.1
5.5.1.2 3-carboxy-cis,cis-muconate cycloisomerase


4-nitrophenol + O2 + NADPH + H+ <=> 1,4-benzoquinone + nitrite + H2O + NADP+ 1.14.13.167 4-nitrophenol 4-monooxygenase
1.14.13.210 4-methyl-5-nitrocatechol 5-monooxygenase


1,2,3,5-Tetrahydroxybenzene + pyrogallol <=> 1,2,3,5-Tetrahydroxybenzene + phloroglucinol 1.97.1.2 pyrogallol hydroxytransferase

N-hydroxyaniline <=> 2-Aminophenol 5.4.4.1 (hydroxyamino)benzene mutase

phenol + O2 + NADPH + H+ <=> catechol + H2O + NADP+ 1.14.13.7 phenol 2-monooxygenase (NADPH)
1.14.14.20 phenol 2-monooxygenase (FADH2)


hydroquinone + O2 + NADPH <=> Hydroxyquinol + NADP+ + H2O 1.14.13
1.14.13.7 phenol 2-monooxygenase (NADPH)
1.14.14.20 phenol 2-monooxygenase (FADH2)



2-hydroxy-1,4-benzoquinone <=> 1,4-benzoquinone + H2O 1.1

anthranilate + O2 + NADH + H+ <=> catechol + CO2 + NH3 + NAD+ 1.14.12.1 anthranilate 1,2-dioxygenase (deaminating, decarboxylating)

benzoate + CoA + ATP <=> benzoyl-CoA + diphosphate + AMP 6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.25 benzoate---CoA ligase
6.2.1.32 anthranilate---CoA ligase
6.2.1.33 4-chlorobenzoate---CoA ligase




2-aminobenzoyl-CoA <=> benzoyl-CoA + NH3 1.4

dihydrophloroglucinol + NADP+ <=> H+ + phloroglucinol + NADPH 1.3.1.57 phloroglucinol reductase

3,4-dihydroxybenzoate + NH3 <=> 4-Aminobenzoic_acid + O2 + 2 H+ 1.14.12

cyclopropanecarboxylic_acid + CoA + ATP <=> cyclopropanecarboxyl-CoA + ADP + phosphate 6.2.1

Benzonitrile + H2O <=> benzoate + NH3 3.5.5.1 nitrilase
3.5.5.5 arylacetonitrilase
3.5.5.7 aliphatic nitrilase



3-hydroxyaminophenol <=> aminohydroquinone 5.4.4.3 3-(hydroxyamino)phenol mutase

Thiobenzamide_S-oxide + NADPH + H+ + O2 <=> Thiobenzamide_S,S-dioxide + NADP+ + H2O 1.14.13

4-nitrophenyl_phosphate + H2O <=> 4-nitrophenol + phosphate + H+ 3.1.16.1 spleen exonuclease
3.1.22.1 deoxyribonuclease II
3.1.3.1 alkaline phosphatase
3.1.3.10 glucose-1-phosphatase
3.1.3.16 protein-serine/threonine phosphatase
3.1.3.18 phosphoglycolate phosphatase
3.1.3.2 acid phosphatase
3.1.3.23 sugar-phosphatase
3.1.3.24 sucrose-phosphate phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.26 4-phytase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.3 phosphoserine phosphatase
3.1.3.31 nucleotidase
3.1.3.32 polynucleotide 3'-phosphatase
3.1.3.36 phosphoinositide 5-phosphatase
3.1.3.38 3-phosphoglycerate phosphatase
3.1.3.39 streptomycin-6-phosphatase
3.1.3.4 phosphatidate phosphatase
3.1.3.41 4-nitrophenylphosphatase
3.1.3.43 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase
3.1.3.44 [acetyl-CoA carboxylase]-phosphatase
3.1.3.48 protein-tyrosine-phosphatase
3.1.3.5 5'-nucleotidase
3.1.3.51 dolichyl-phosphatase
3.1.3.58 sugar-terminal-phosphatase
3.1.3.6 3'-nucleotidase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase
3.1.3.72 5-phytase
3.1.3.73 adenosylcobalamin/alpha-ribazole phosphatase
3.1.3.74 pyridoxal phosphatase
3.1.3.75 phosphoethanolamine/phosphocholine phosphatase
3.1.3.76 lipid-phosphate phosphatase
3.1.3.8 3-phytase
3.1.3.9 glucose-6-phosphatase
3.1.4.16 2',3'-cyclic-nucleotide 2'-phosphodiesterase
3.1.4.2 glycerophosphocholine phosphodiesterase
3.1.4.37 2',3'-cyclic-nucleotide 3'-phosphodiesterase
3.1.4.4 phospholipase D
3.1.4.46 glycerophosphodiester phosphodiesterase
3.1.7.6 farnesyl diphosphatase
3.11.1.1 phosphonoacetaldehyde hydrolase
3.6.1.11 exopolyphosphatase
3.6.1.5 apyrase
3.6.1.7 acylphosphatase
3.6.1.9 nucleotide diphosphatase
3.9.1.1 phosphoamidase
3.9.1.3 phosphohistidine phosphatase
5.4.2.6 beta-phosphoglucomutase
7.2.2.13 Na+/K+-exchanging ATPase
7.6.2.1 P-type phospholipid transporter



















































thiobenzamide + O2 + NADPH + H+ <=> Thiobenzamide_S-oxide + NADP+ + H2O 1.14.13

Vanillin + H2O + NAD+ <=> vanillic_acid + NADH + H+ 1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.29 aryl-aldehyde dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+)
1.2.1.67 vanillin dehydrogenase
1.2.1.7 benzaldehyde dehydrogenase (NADP+)






terephthalate + H2O <=> benzoate + HCO3- not assigned

4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde + NADP+ <=> 2-Pyrone-4,6-dicarboxylate + NADPH + H+ 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

(S)-Mandelate <=> (R)-mandelate 5.1.2.2 mandelate racemase

syringic_acid + tetrahydrofolate <=> 5-methoxygallic_acid + 5-methyltetrahydrofolate 2.1.1
2.1.1.341 vanillate/3-O-methylgallate O-demethylase


H+ + 5-carboxyvanillate <=> vanillic_acid + CO2 4.1.1

3-hydroxy-5-oxohexanoyl-CoA + CoA <=> (S)-3-hydroxybutyryl-CoA + acetyl-CoA 2.3.1

Aminoparathion + H2O <=> H+ + diethyl_thiophosphate + 4-Aminophenol 3.1.8.1 aryldialkylphosphatase

Benzonitrile + H2O <=> Benzamide 4.2.1.84 nitrile hydratase

4-Aminophenol + H2O <=> 1,4-benzoquinone + NH3 1.4

vanillic_acid + tetrahydrofolate <=> 3,4-dihydroxybenzoate + 5-methyltetrahydrofolate 2.1.1.341 vanillate/3-O-methylgallate O-demethylase

H+ + gallic_acid <=> CO2 + pyrogallol 4.1.1.59 gallate decarboxylase
4.1.1.61 4-hydroxybenzoate decarboxylase


2,2'',3-Trihydroxy-3''-methoxy-5,5''-dicarboxybiphenyl + O2 <=> 4-[2-(5-Carboxy-2-hydroxy-3-methoxyphenyl)-2-oxoethylidene]-2-hydroxy-2-pentenedioate not assigned

vanillic_acid + cob(I)alamin <=> 3,4-dihydroxybenzoate + methylcobalamin 2.1.1

o-Hydroxylaminobenzoate <=> 3-Hydroxyanthranilate 5.4.99

4-nitrophenol + NADH + O2 + H+ <=> 4-nitrocatechol + NAD+ + H2O 1.14.13.29 4-nitrophenol 2-monooxygenase

4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate + H2O <=> 4-oxalomesaconate + methanol not assigned

4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde <=> 4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde not assigned

4-nitrophenyl + O2 + NADH <=> catechol + nitrite + NAD+ 1.14.12.23 nitroarene dioxygenase

paraoxon + H2O <=> diethyl_phosphate + 4-nitrophenol + H+ 3.1.1.1 carboxylesterase
3.1.1.2 arylesterase
3.1.1.25 1,4-lactonase
3.1.1.7 acetylcholinesterase
3.1.1.81 quorum-quenching N-acyl-homoserine lactonase
3.1.2.12 S-formylglutathione hydrolase
3.1.3.1 alkaline phosphatase
3.1.4.2 glycerophosphocholine phosphodiesterase
3.1.4.46 glycerophosphodiester phosphodiesterase
3.1.8.1 aryldialkylphosphatase
3.1.8.2 diisopropyl-fluorophosphatase











4-Aminobenzoic_acid + O2 + NADH + H+ <=> 4-Aminophenol + CO2 + H2O + NAD+ 1.14.13.27 4-aminobenzoate 1-monooxygenase

cyclopropanecarboxyl-CoA <=> crotonyl-CoA 5.5.1

2-amino-5-oxocyclohex-1-enecarboxyl-CoA + 2 H2O <=> Cyclohexan-1,4-dione + NH3 + CO2 + CoA not assigned

dihydrophloroglucinol + H2O <=> 3-Hydroxy-5-oxohexanoate + H+ 3.7.1

benzaldehyde + H2O + NADP+ <=> benzoate + NADPH + H+ 1.1.1.195 cinnamyl-alcohol dehydrogenase
1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]
1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
1.2.1.79 succinate-semialdehyde dehydrogenase (NADP+)










H2O + (R)-mandelamide <=> NH3 + (R)-mandelate 3.5.1.86 mandelamide amidase

O2 + 3,4-dihydroxybenzoate <=> H+ + 4-carboxy-2-hydroxy-cis,cis-muconate_6-semialdehyde 1.13.11.8 protocatechuate 4,5-dioxygenase

4-sulfocatechol + O2 <=> H+ + 3-sulfomuconate 1.13.11
1.13.11.3 protocatechuate 3,4-dioxygenase


(S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate + acceptor <=> 4-hydroxyphenylglyoxylate + reduced_acceptor 1.1.99.31 (S)-mandelate dehydrogenase
1.1.99.B9


parathion + H2O <=> H+ + diethyl_thiophosphate + 4-nitrophenol 3.1.8.1 aryldialkylphosphatase

3-hydroxy-5-oxohexanoyl-CoA + acetate <=> 3-Hydroxy-5-oxohexanoate + acetyl-CoA 2.8.3.8 acetate CoA-transferase

parathion + reduced_flavodoxin + O2 <=> paraoxon + flavin + sulfur + H2O 1.14.14.1 unspecific monooxygenase

benzoate + reduced_flavodoxin + O2 <=> 4-hydroxybenzoate + flavin + H2O 1.14.14.1 unspecific monooxygenase
1.14.14.92 benzoate 4-monooxygenase


4-Aminocatechol + H2O <=> Hydroxyquinol + NH3 not assigned

benzoyl-CoA + oxidized_ferredoxin + H2O <=> 4-hydroxybenzoyl-CoA + reduced_ferredoxin 1.1.7.1 4-hydroxybenzoyl-CoA reductase

phenol + ATP + H2O <=> Phenyl_phosphate + AMP + phosphate + H+ 2.7.9

phenylboronic_acid + O2 <=> phenol + Boric_acid 1.14

3-hydroxyaminophenol <=> 4-Aminocatechol 5.4.4.3 3-(hydroxyamino)phenol mutase

5-methoxygallic_acid + tetrahydrofolate <=> gallic_acid + 5-methyltetrahydrofolate 2.1.1.341 vanillate/3-O-methylgallate O-demethylase

5,5''-Dehydrodivanillate + O2 + NADPH + H+ <=> 2,2'',3-Trihydroxy-3''-methoxy-5,5''-dicarboxybiphenyl + NADP+ + H2O + formaldehyde not assigned

aminohydroquinone + H2O <=> Hydroxyquinol + NH3 not assigned

2-Aminophenol + O2 <=> 2-aminomuconate_6-semialdehyde 1.13.11.74 2-aminophenol 1,6-dioxygenase

H+ + 4-hydroxyphenylglyoxylate <=> 4-hydroxybenzaldehyde + CO2 4.1.1.7 benzoylformate decarboxylase

anthranilate + O2 + NADPH + H+ <=> catechol + CO2 + NH3 + NADP+ 1.14.12.1 anthranilate 1,2-dioxygenase (deaminating, decarboxylating)

guaiacol + reduced_flavodoxin + O2 <=> catechol + flavin + formaldehyde + H2O 1.14.14

4-nitrocatechol + O2 + 3 H+ <=> Hydroxyquinol + nitrite + H2O 1.14

Sulfanilic_acid + O2 + 2 H+ <=> 4-sulfocatechol + NH3 1.14.12

(S)-3-hydroxybutyryl-CoA <=> H2O + crotonyl-CoA 1.3.8.7 medium-chain acyl-CoA dehydrogenase
4.2.1.116 3-hydroxypropionyl-CoA dehydratase
4.2.1.150 short-chain-enoyl-CoA hydratase
4.2.1.17 enoyl-CoA hydratase




Thiobenzamide_S,S-dioxide <=> Benzonitrile not assigned

(S)-Mandelate + tetrahydropteridine + O2 <=> (S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate + a_4a-hydroxy-5,6,7,8-tetrahydropteridine 1.14.16.6 mandelate 4-monooxygenase

N-hydroxyaniline + NADP+ <=> nitrosobenzene + NADPH + H+ 1.7.1.16 nitrobenzene nitroreductase

parathion + 3 reduced_acceptor <=> Aminoparathion + 3 acceptor + 2 H2O not assigned

anthranilate + CoA + ATP <=> 2-aminobenzoyl-CoA + AMP + diphosphate 6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.25 benzoate---CoA ligase
6.2.1.32 anthranilate---CoA ligase



Sulfanilic_acid + 4-Aminobenzoic_acid <=> 4-Carboxy-4''-sulfoazobenzene + 4 H+ 1.7.1

H+ + 2,3-Dihydroxybenzoate <=> CO2 + catechol 4.1.1.103 gamma-resorcylate decarboxylase
4.1.1.46 o-pyrocatechuate decarboxylase
4.1.1.91 salicylate decarboxylase



benzoyl_phosphate + H2O <=> benzoate + phosphate 3.6.1.7 acylphosphatase

2-Hydroxy-2-hydropyrone-4,6-dicarboxylate + NAD+ <=> 2-Pyrone-4,6-dicarboxylate + NADH + H+ 1.1.1.312 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

vanillic_acid + O2 + NADH + H+ <=> 3,4-dihydroxybenzoate + formaldehyde + NAD+ + H2O 1.14.13.82 vanillate monooxygenase

4-hydroxybenzaldehyde + NAD+ + H2O <=> 4-hydroxybenzoate + NADH + H+ 1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.29 aryl-aldehyde dehydrogenase
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+)
1.2.1.65 salicylaldehyde dehydrogenase
1.2.1.67 vanillin dehydrogenase
1.2.1.96 4-hydroxybenzaldehyde dehydrogenase (NADP+)







CoA + 4-hydroxybenzoate + ATP <=> 4-hydroxybenzoyl-CoA + diphosphate + AMP 6.2.1.27 4-hydroxybenzoate---CoA ligase

(S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate + O2 + H+ <=> 4-hydroxybenzaldehyde + CO2 + H2O2 1.1.3.19 4-hydroxymandelate oxidase (decarboxylating)

2-aminobenzoyl-CoA + O2 + NADH + H+ <=> 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NAD+ 1.14.13.40 anthraniloyl-CoA monooxygenase

2-aminobenzoyl-CoA + O2 + NADPH + H+ <=> 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + NADP+ 1.14.13.40 anthraniloyl-CoA monooxygenase

H+ + 2-nitrobenzoate + NADPH <=> o-Hydroxylaminobenzoate + NADP+ + H2O 1.7.1

aniline + O2 <=> catechol + NH3 1.14

5-methoxygallic_acid + O2 <=> H+ + 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate 1.13.11
1.13.11.8 protocatechuate 4,5-dioxygenase


4-[2-(5-Carboxy-2-hydroxy-3-methoxyphenyl)-2-oxoethylidene]-2-hydroxy-2-pentenedioate + H2O <=> 5-Carboxyvanillic_acid + 4-Methylene-2-oxoglutarate not assigned

H+ + 4-hydroxybenzoate <=> CO2 + phenol 4.1.1.103 gamma-resorcylate decarboxylase
4.1.1.61 4-hydroxybenzoate decarboxylase


o-Hydroxylaminobenzoate + 2 H+ <=> anthranilate + H2O 1.4

4-Aminobenzoic_acid + O2 + NADPH + H+ <=> 4-Aminophenol + CO2 + H2O + NADP+ 1.14.13.27 4-aminobenzoate 1-monooxygenase

3-Nitrophenol + 2 NADH + 2 H+ <=> 3-hydroxyaminophenol + 2 NAD+ + H2O 1.7.1

4-hydroxybenzaldehyde + NADP+ + H2O <=> 4-hydroxybenzoate + NADPH + H+ 1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.67 vanillin dehydrogenase
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
1.2.1.96 4-hydroxybenzaldehyde dehydrogenase (NADP+)





H+ + anthranilate + O2 + NADPH <=> NH3 + NADP+ + 2,3-Dihydroxybenzoate 1.14.13.35 anthranilate 3-monooxygenase (deaminating)

Benzamide + H2O <=> benzoate + NH3 3.5.1.13 aryl-acylamidase
3.5.1.19 nicotinamidase
3.5.1.4 amidase
3.5.5.1 nitrilase




Phenyl_phosphate + CO2 + H2O <=> H+ + 4-hydroxybenzoate + phosphate 4.1.1.61 4-hydroxybenzoate decarboxylase
6.4.1


diethyl_thiophosphate + H2O <=> diethyl_phosphate + Sulfide 3.13.1

Visualization of the pathway